Appendix A -- Bibliography

Allen, D.M.; Lehman, J.S.; Green, T.A.; Lindegren, M.L.; Onorato, I.M.; and Forrester, W.

HIV infection among homeless adults and runaway youth, United States, 1989-1992. AIDS 8(11):1593-1598, 1994.


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Alliegro, M.B.; Dorrucci, M.; Phillips, A.N.; Pezzotti, P.; Boros, S.; Zaccarelli, M.; Pristera, R.; and Rezza, G.

Incidence and consequences of pregnancy in women with known duration of HIV infection. Archives of Internal Medicine 157(22):2585-2590, 1997.


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Amass, L.; Bickel, W.K.; Higgins, S.T.; and Hughes, J.R.

A preliminary investigation of outcome following gradual or rapid buprenorphine detoxification. Journal of Addictive Diseases 13(3):33-45, 1994.


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American Academy of Neurology, AIDS Task Force.

Criteria for diagnosis of HIV-1 associated dementia complex: Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection. Neurology 41:778-784, 1991.


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American Psychiatric Association (APA).

Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: APA, 1994.

American Psychiatric Association (APA).

Practice Guidelines for Treatment of Patients With Substance Use Disorders; Alcohol, Cocaine, Opioids. Washington, DC: APA, 1995.

American Society of Addiction Medicine (ASAM).

Guidelines for HIV Infection and AIDS in Addiction Treatment. Chevy Chase, MD: ASAM, 1998.

American Thoracic Society. Edsall JR, Awe RJ, Bunyan SB, Hackney RL Jr, Iseman MD, Reagan WP.

Treatment of tuberculosis in alcoholic patients. American Review of Respiratory Disease 116:559-560, 1977.


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Americans With Disabilities Act.

42 U.S.C. _12101 et seq. (1992).

Anand, A.; Carmosino, L.; and Glatt, A.E.

Evaluation of recalcitrant pain in HIV-infected hospitalized patients. Journal of Acquired Immune Deficiency Syndromes 7(1):52-56, 1994.


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Angelone, S.M.; Bellini, L.; Di Bella, D.; and Catalano, M.

Effects of fluvoxamine and citalopram in maintaining abstinence in a sample of Italian detoxified alcoholics. Alcohol and Alcoholism 33(2):151-156, 1998.


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Ashery, R.S.

Issues in AIDS training for substance abuse workers. Journal of Substance Abuse Treatment 9(1):15-19, 1992.


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Asim, J.

"Black paranoia far-fetched? Maybe, but understandable." The Phoenix Gazette Op-Ed:A13, February 23, 1993.

Avins, A.L.; Woods, W.J.; Lindan, C.P.; Hudes, E.S.; Clark, W.; and Hulley, S.B.

HIV infection and risk behaviors among heterosexuals in alcohol treatment programs. JAMA 271(7):515-518, 1994.


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Baker, A.; Kochan, N.; Dixon, J.; Wodak, A.; and Heather, N.

HIV risk-taking behaviour among injecting drug users currently, previously, and never enrolled in methadone treatment. Addiction 90(4):545-554, 1995.


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Ball, J.C.; Lange, W.R.; Myers, C.P.; and Friedman, S.R.

Reducing the risk of AIDS through methadone maintenance treatment. Journal of Health and Social Behavior 29(3):214-226, 1988.


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Ball, J.C., and Ross, A.

The Effectiveness of Methadone Maintenance Treatment. New York: Springer-Verlag, 1991.

Bandura, A.

Self-efficacy: Toward a unifying theory of behavioral change. Psychological Review 84(2):191-215, 1977.


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Banks, A., and Gartrell, N.K.

Lesbians in the medical setting. In: Cabaj, R.P., and Stein, T.S., eds. Homosexuality and Mental Health: A Comprehensive Review. Washington, DC: American Psychiatric Press, 1996. pp. 659-671.

Barre-Sinoussi, F.; Chermann, J.C.; Rey, F.; Nugeyre, M.T.; Chamaret, S.; Gruest, J.; Dauguet, C.; Axler-Blin, C.; Vezinet-Brun, F.; Rouzioux, C.; Rozenbaum, W.; and Montagnier, L.

Isolation of T-lymphotropic retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS). Science 220(4599):868-871, 1983.


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Bartlett, J.G.

Medical Management of HIV Infection. Baltimore, MD: Johns Hopkins AIDS Service, 1999. http://www.hopkins-aids.edu/publications/index_pub.html [Accessed August 4, 1999].

Batki, S.L.

Treatment of intravenous drug abusersusers with AIDS: The role of methadone maintenance. Journal of Psychoactive Drugs 20(2):213-216, 1988.


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Batki, S.L.; Blake, M.; Gruber, V.; Milovitch, E.; Ouye, G.; Nathan, K.; and Warren, R.

Standards of Care: Client Assessment and Treatment Protocol. Unpublished tool used by the Opiate Treatment Outpatient Program, San Francisco General Hospital, University of California at San Francisco, 1999.

Batki, S.L.; Ferrando, S.J.; Manfredi, L.; London, J.; Pattillo, J.; and Delucchi, K.

Psychiatric disorders, drug use, and medical status in injection drug users with HIV disease. American Journal on Addictions 5(3):249-258, 1996.

Batki, S.L., and London, J.

Drug abuse treatment for HIV-infected patients. In: Sorensen, J.L.; Wermuth, L.A.; Gibson, D.R.; Choi, K.-H., Guydish, J.R.; and Batki, S.L., eds. Preventing AIDS in Drug Abusers and Their Sexual Partners. New York: Guilford Press, 1991. pp. 77-98.

Beatty, R.L.

"Alcoholism and the adult gay male population of Pennsylvania." Master's thesis. Harrisburg, PA: Pennsylvania State University, 1983.

Beck, A.T., and Steer, R.A.

Beck Depression Inventory. San Antonio, TX: Psychological Corporation, 1993.

Bell, A.P., and Weinberg, M.S.

Homosexualities: A Study of Diversities Among Men and Women. New York: Simon & Schuster, 1978.

Bell, A.P.; Weinberg, M.S.; and Hammersmith, S.K.

Sexual Preference; Its Development in Men and Women. Bloomington, IN: Indiana University Press, 1981.

Berglund, M., and Ojehagen, A.

The influence of alcohol drinking and alcohol use disorders on psychiatric disorders and suicidal behavior. Alcoholism, Clinical and Experimental Research 22(7 Suppl):333S-345S, 1998.


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Berlin, E.A., and Fowkes, Jr., N.C.

A teaching framework for cross-cultural health care. Western Journal of Medicine 139(6):934-938, 1983.


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Bickel, W.K., and Amass, L.

The relationship of mean daily blood alcohol levels to admission MAST, clinic absenteeism, and depression in alcoholic methadone patients. Drug and Alcohol Dependence 32:113-118, 1993.


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Bickel, W.K.; Amass, L.; Higgins, S.T.; Badger, G.J.; and Esch, R.A.

Effects of adding behavioral treatment to opioid detoxification with buprenorphine. Journal of Consulting and Clinical Psychology 65(5):803-810, 1997.


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Bindman, A.B.; Osmond, D.; Hecht, F.M.; Lehman, J.S.; Vranizan, K.; Keane, D.; Reingold, A.; and the Multistate Evaluation of Surveillance of HIV (MESH) Study Group.

Multistate evaluation of anonymous HIV testing and access to medical care. JAMA 280(16):1416-1420, 1998.


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Bloomfield, K.

A comparison of alcohol consumption between lesbians and heterosexual women in an urban population. Drug and Alcohol Dependence 33(3):257-269, 1993.


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Boccellari, A.A.; Chambers, D.B.; Dilley, J.W.; Shore, M.D.; Tauber, M.A.; Moss, A.R.; and Osmond, D.H.

Relationship of beta 2 microglobulin and CD4 counts to neuropsychological performance in HIV-1-infected intravenous drug abusers. Journal of Acquired Immune Deficiency Syndromes 7(10):1040-1049, 1994.


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Boccellari, A.A.; Dilley, J.W.; Chambers, D.B.; Yingling, C.D.; Tauber, M.A.; Moss, A.R.; and Osmond, D.H.

Immune function and neuropsychological performance in HIV-1-infected homosexual men. Journal of Acquired Immune Deficiency Syndromes 6(6):592-601, 1993a.


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Boccellari, A.A.; Dilley, J.W.; Yingling, C.D.; Chambers, D.B.; Tauber, M.A.; Moss, A.R.; and Osmond, D.H.

Relationship of CD4 counts to neurophysiological function in HIV-1-infected homosexual men. Archives of Neurology 50(5):517-521, 1993b.


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Bokos, P.J.; Mejta, C.L.; Mickenberg, J.H.; and Monks, R.L.

Case management: An alternative approach to working with intravenous drug abusers. In: Ashery, R.S., ed. Progress and Issues in Case Management. NIDA Research Monograph Series, Number 127. DHHS Pub. No. (ADM) 92-1946. Rockville, MD: National Institute on Drug Abuse, 1992. pp. 92-111.

Booth, R.E.; Kwiatkowski, C.; Iguchi, M.Y.; Pinto, F.; and John, D.

Facilitating treatment entry among out-of-treatment injection drug users. Public Health Reports 113 (Suppl. 1):116-128, 1998.


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Booth, R.E., and Wiebel, W.W.

Effectiveness of reducing needle-related risks for HIV through indigenous outreach to injection drug users. American Journal on Addictions 1(4):277-287, 1992.

Bortolotti, F.; Stivanello, A.; Armi, Dall', A.; Rinaldi, R.; and La Grasto, F.

AIDS information campaign has significantly reduced risk factors for HIV infection in Italian drug abusers. Journal of Acquired Immune Deficiency Syndromes 1(4):412-413, 1988.


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Bozzette, S.A.; Finkelstein, D.M.; Spector, S.A.; Frame, P.; Powderly, W.G.; He, W.; Phillips, L.; Craven, D.; van der Horst, C.; and Feinberg, J.

A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. New England Journal of Medicine 332(11):693-699, 1995.


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Bradford, J., and Ryan, C.

"National Lesbian Health Care Survey: Mental Health Implications." Washington, DC: National Lesbian and Gay Health Foundation, 1987.

Bradley-Springer, L.A.

The complex realities of primary prevention for HIV infection in a "just do it" world. Nursing Clinics of North America 34(1):49-70, 1999.


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Branson, B.M.

Home sample collection tests for HIV infection. JAMA 280(19):1699-1701, 1998.


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Breitbart, W.

Suicide risk and pain in cancer and AIDS patients. In: Chapman, C.R., and Foley, K.M., eds. Current and Emerging Issues in Cancer Pain: Research and Practice. New York: Raven Press, 1993. pp. 49-65.

Breitbart, W.; Passik, S.; Bronaugh, T.; Zale, C.; Bluestine, S.; Gomez, M.; Galer, B.; and Portney, R.

Pain in the ambulatory AIDS patient: Prevalence and psychosocial correlates. Proceedings of the 38th Annual Meeting, Academy of Psychosomatic Medicine, Atlanta, GA, October 17-20, 1991.

Brindis, C.; Pfeffer, R.; and Wolfe, A.

A case management program for chemically dependent clients with multiple needs. Journal of Case Management 4(1):22-28, 1995.

Brindis, C., and Theidon, K.S.

The role of case management in substance abuse treatment services for women and their children. Journal of Psychoactive Drugs 29(1):79-88, 1997.


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Broers, B.; Morabia, A.; and Hirschel, B.

A cohort study of drug abusers' compliance with zidovudine treatment. Archives of Internal Medicine 154(10):1121-1127, 1994.


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Brooner, R.; Kidorf, M.; King, V.; Beilenson, P.; Svikis, D.; and Vlahov, D.

Reduced drug use in needle exchange participants. International Conference on AIDS 12:671 (Abstract No. 33408), 1998.

Buckingham, S.L., and Van Gorp, W.G.

HIV-associated dementia: A clinician's guide to early detection, diagnosis, and intervention. Families in Society: The Journal of Contemporary Human Services 75(6):333-345, 1994.

Bux, D.A.; Iguchi, M.Y.; Lidz, V.; Baxter, R.C.; and Platt, J.J.

Participation in an outreach-based coupon distribution program for free methadone detoxification. Hospital and Community Psychiatry 44(11):1066-1072, 1993.

Cabaj, R.P.

Homosexuality and neurosis: Considerations for psychotherapy. Journal of Homosexuality 15(1-2):13-23, 1988.


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Cabaj, R.P.

AIDS and chemical dependency: Special issues and treatment barriers for gay and bisexual men. Journal of Psychoactive Drugs 21(4):387-393, 1989.


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Cabaj, R.P.

Substance abuse in gay men, lesbians, and bisexual individuals. In: Cabaj, R.P., and Stein, T.S., eds. Textbook of Homosexuality and Mental Health. Washington, DC: American Psychiatric Press, 1996. pp. 783-799.

Cabaj, R.P.

Gays, lesbians, and bisexuals. In: Lowinson, J.H.; Ruiz, P.; Millman, R.B.; and Langrod, J.G., eds. Substance Abuse: A Comprehensive Textbook, 3rd ed. Baltimore, MD: Williams & Wilkins, 1997. pp. 725-733.

Cabaj, R.P., and Stein, T.S., eds.

Textbook of Homosexuality and Mental Health. Washington, DC: American Psychiatric Press, 1996.

California Department of Corrections.

What percentage of the California correctional population has a history of substance abuse? California Correctional Statistics, CCS 1-98, July 1998. http://www.cdc.state.ca.us/reports/offender.htm [Accessed July 12, 1998].

Calsyn, D.A.; Saxon, A.J.; Freeman, Jr., G.; and Whittaker, S.

Ineffectiveness of AIDS education and HIV antibody testing in reducing high-risk behaviors among injection drug users. American Journal of Public Health 82:573-575, 1992.


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Calzavara, L.M.; Coates, R.A.; Raboud, J.M.; Farewell, V.T.; Read, S.E.; Shephered, F.A.; Fanning, M.M.; and MacFadden, D.

Ongoing high-risk sexual behaviors in relation to recreational drug use in sexual encounters. Analysis of 5 years of data from the Toronto Sexual Contact Study. Annals of Epidemiology 3(3):272-280, 1993.


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Cameron, D.W.; Heath-Chiozzi, M.; Danner, S.; Cohen, C.; Kravcik, S.; Maurath, C.; Sun, E.; Henry, D.; Rode, R.; Potthoff, A.; and Leonard, J.

Randomised, placebo-controlled trial of ritonavir in advanced HIV-1 disease. Lancet 351(9102):543-549, 1998.


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Cameron, D.W.; Pavon, J.; Rodriguez de Castro, F.; Diaz, F.; Julia, G.; Cayla, J.; and Cabrera, P.

"Prolongation of life and prevention of AIDS complications in advanced HIV immunodeficiency with ritonavir." Eleventh International Conference on AIDS, Vancouver, Canada, July 7-12, 1996.

Cameron, D.W.; Simonsen, J.N.; D'Costa, L.J.; Ronald, A.R.; Maitha, G.M.; Gakinya, M.N.; Cheang, M.; Ndinya-Achola, J.O.; Piot, P.; and Brunham, R.C.

Female to male transmission of human immunodeficiency virus type 1: Risk factors for seroconversion in men. Lancet 2(8660):403-407, 1989.


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Carpenter, C.C.; Fischl, M.A.; Hammer, S.M.; Hirsch, M.S.; Jacobsen, D.M.; Katzenstein, D.A.; Montaner, J.S.; Richman, D.D.; Saag, M.S.; Schooley, R.T.; Thompson, M.A.; Vella, S.; Yeni, P.G.; and Volberding, P.A.

Antiretroviral therapy for HIV infection in 1996. Recommendations of an international panel. JAMA 276(2):146-154, 1996.


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Carpenter, C.C.; Fischl, M.A.; Hammer, S.G.; Hirsch, M.S.; Jacobsen, D.M.; Katzenstein, D.A.; Montaner, J.S.; Richman, D.D.; Saag, M.S.; Schooley, R.T.; Thompson, M.A.; Vella, S.; Yeni, P.G.; and Volberding, P.A.

Antiretroviral therapy for HIV-infection in 1997. Updated recommendations of the International AIDS Society-USA Panel. JAMA 277(24):1962-1969, 1997.


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Carpenter, C.C.; Fischl, M.A.; Hammer, S.M.; Hirsch, M.S.; Jacobsen, D.M.; Katzenstein, D.A.; Montaner, J.S.; Richman, D.D.; Saag, M.S.; Schooley, R.T.; Thompson, M.A.; Vella, S.; Yeni, P.G.; and Volberding, P.A.

Antiretroviral therapy for HIV infection in 1998: Updated recommendations of the International AIDS Society-USA Panel. JAMA 280(1):78-86, 1998.


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Carroll, J.

The negative attitudes of some general nurses towards drug misusers. Nursing Standard 9(34):36-38, 1995.


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Casadonte, P.P.; Des Jarlais, D.C.; Friedman, S.R.; and Rotrosen, J.P.

Psychological and behavioral impact among intravenous drug abusers of learning HIV test results. International Journal of the Addictions 25:409-426, 1990.

Castro, K.G.; Ward, J.W.; Slutsker, L.; Buehler, J.W.; Jaffe, H.W.; and Berkelman, R.L.

1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults. Morbidity and Mortality Weekly Report 41, December 18, 1992. http://www.cdc.gov/mmwr [Accessed August 20, 1999].

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Appendix B -- Glossary

Abstinence:

Complete cessation of substance-using behavior.

Acute retroviral syndrome:

An array of symptoms that arises after initial infection with HIV that includes fever, sore throat, swollen glands, muscle and joint pain, nausea, and rash.

Adherence:

Strict observation of a prescribed treatment regimen, including correct dosage and number of doses per day, as well as taking doses with or without food or other medications.

Agranulocytosis:

A sudden, severe drop in white blood cell count that can occur upon the administration of certain HIV medications.

AIDS (acquired immunodeficiency syndrome):

AIDS is the end stage of HIV disease and is characterized by a severe reduction in CD4+ T cells. At this point, an infected person has a very weak immune system and is vulnerable to contracting life-threatening infections.

Antiretroviral:

A medication that weakens or halts the reproduction of retroviruses such as HIV.

Blood-brain barrier:

A physical barrier between the blood vessels and the brain that only allows certain substances to pass through and enter the brain.

CD4+ T cell count:

The number of CD4+ T cells in a milliliter of blood. These cells (white blood cells within the immune system) are constantly measured in HIV-infected clients because their number reflects the overall health of the immune system.

Case finding:

A component of outreach that identifies individuals at higher risk for HIV infection and that stresses HIV/AIDS prevention, along with the distribution of items to facilitate compliance with risk reduction techniques.

Combination therapy:

The treatment of HIV disease with multiple medications. Combinations of three or more different medicines are used to treat a client, with each medicine working in a different way to stop the virus. While this is the most effective treatment to date, once combination therapy is begun, it must not be stopped because the virus could then develop resistance to these medications.

Cross-resistance:

Resistance that can develop in the HIV virus once a medication from a certain class is used (e.g., protease inhibitors, nucleosides) to treat it. The virus not only becomes resistant to one particular drug but also becomes resistant to some or all of the other drugs from that class. For this reason, it is widely believed that the best chance for success in HIV treatment is with the first treatment regimen.

Cultural competence:

An aspect of treatment that takes into account the cultural heritage of the client. Culturally competent providers recognize the customs, beliefs, and social forms of the racial, religious, or social group to which the client belongs and work within these parameters to interact successfully with the client.

Cytomegalovirus (CMV):

Any of the group of herpes viruses that appear as opportunistic infections in patients with HIV disease, generally in the latter stages of AIDS. CMV most commonly causes retinitis, which can lead to blindness if untreated, and may also cause gastrointestinal, adrenal, pulmonary, and other systemic problems.

Drug interaction:

The positive or negative effect that one medication has on another when an HIV-infected client is taking both.

Endocarditis:

Bacterial endocarditis is a well-recognized complication of unsterile injection drug use that produces inflammation of the endocardium (the lining of the heart). It can also appear as an HIV-related opportunistic infection.

HAART (highly active antiretroviral therapy):

Aggressive combination therapy that usually includes a powerful protease inhibitor medication.

Harm reduction:

An approach to treatment that emphasizes incremental decreases in substance abuse or HIV risk behaviors as treatment goals. This method attempts to keep clients in treatment even if complete abstinence is not achieved.

Herpes zoster (shingles):

A virus that often appears as an initial indication of HIV disease and begins with itching or pain on only one side of the face or body, followed by a rash that looks like chicken pox or poison ivy.

HIV (human immunodeficiency virus):

The retrovirus that causes AIDS in humans. HIV is transmitted through direct contact with human bodily fluids; roughly 10 years after infection, AIDS-defining conditions begin to occur. AIDS is characterized by a severe reduction in CD4+ T cells, which greatly weakens the immune system and leaves the patient vulnerable to contracting life-threatening infections. New medicines can control HIV and extend the life of the patient; however, AIDS is inevitably fatal.

Homophobia:

An irrational aversion to gay men and lesbians and to their lifestyle.

Hospice:

A program or facility that provides care for clients in the last stages of a terminal disease such as AIDS and creates a compassionate environment in which clients can die peacefully.

Leukoplakia:

A virus that causes white patches in the mouth and is one of the initial indications of HIV infection.

Lymphadenopathy:

Swollen lymph nodes, the most common symptom during the HIV latency period. The lymph nodes can be found around the neck and under the arms and contain cells that fight infections. When an infection is present, lymph nodes usually swell. Inside the lymph nodes HIV is trapped and destroyed, but eventually the HIV breaks down the tissue of the nodes and spills into the rest of the body.

Monotherapy:

Treatment of HIV infection with only one medication, usually AZT. This was the standard treatment for HIV before 1995 and is now outdated.

MSMs:

Men who have sex with men.

Neutropenia:

Bone marrow suppression, which can occur upon the administration of certain HIV medications.

Nonnucleoside reverse transcriptase inhibitor (NNRTI):

A type of medication that binds to HIV's reverse transcriptase enzyme and stops the virus from replicating. NNRTI medications include delaviridine, efavirenz, and nevirapine.

Nucleoside analog:

A drug that mimics HIV's genetic material and halts it from reproducing. This class of drugs includes AZT, abacavir, didanosine, zalcitabine, stavudine, and lamivudine.

Opportunistic infection:

An infection that usually does not harm a healthy person but that can cause a life-threatening illness in someone with a compromised immune system.

Perinatal HIV transmission (vertical transmission):

Transmission of HIV from a mother to her child either in the uterus, during birth, or through breast-feeding.

Peripheral neuropathy:

A condition in which the peripheral nerves of the hands or feet are afflicted, producing numbness, tingling, pain, or weakness.

Phlebotomy:

The act of drawing blood.

Pneumocystis carinii pneumonia (PCP):

PCP is the most common AIDS-related infection and is characterized by a dry cough, fever, night sweats, and increasing shortness of breath. Since the late 1980s, the widespread use of PCP prophylaxis has resulted in a dramatic decrease in the incidence of this opportunistic infection. However, despite the availability of effective prophylaxis, PCP is still the most common opportunistic infection; many patients who develop PCP are unaware of their HIV status and hence are not receiving prophylaxis.

Postexposure prophylaxis (PEP):

Antiretroviral therapy that is administered within 72 hours after exposure to HIV in an attempt to eradicate the virus from the body.

Protease inhibitor:

One of a powerful class of drugs used in combination therapy that acts by interfering with the protease enzyme that cuts HIV proteins into the small pieces required to create new copies of the virus. This slows or halts the replication of HIV. Protease inhibitors include indinavir, nelfinavir, ritonavir, and saquinavir.

Reverse transcriptase inhibitor (RTI):

A drug that halts HIV replication by interfering with the reverse transcriptase enzyme used by the HIV virus to transform its genetic material into a form that can be used to produce more viruses. This class of drugs includes nucleoside analogs like AZT and lamivudine.

Risk reduction:

An approach to treatment that emphasizes graduated behavior change rather than immediate abstinence. By identifying areas of risk in the client's life, such as sexual risk or needle sharing, the provider can discuss strategies with the client for avoiding or reducing them.

SEPs:

Syringe exchange programs.

Seroprevalence:

Frequency of presence of antibodies in blood serum as a result of infection.

STDs:

Sexually transmitted diseases.

Substance:

A drug of abuse, a medication, or a toxin.

Substance abuse:

A pattern of substance use that results in harmful consequences for the abuser. This condition is not as severe as substance dependence.

Substance dependence:

Repeated self-administration of a substance that usually results in tolerance, withdrawal, and compulsive substance-abusing behavior.

Thrush:

Oral candidiasis, or thrush, is a symptom of initial HIV infection and usually appears as white plaques at the back of the mouth. Without treatment, thrush often spreads throughout the mouth and can affect the esophagus in persons with advanced disease, leading to severe pain on swallowing and the need for prolonged systemic treatment.

Toxoplasmosis:

An AIDS-defining symptom caused by infection with the protozoan toxoplasma and one of the two most common brain infections in HIV. Toxoplasmosis, which produces seizures, usually does not appear until a client's CD4+ T cell count drops below 100.

Triple combination therapy:

Treatment involving three medications, which can lower the rate of disease progression and mortality more than can two medicines alone. Triple combination therapy was developed after combination-resistant forms of HIV began to appear.

Viral load:

The level of HIV circulating in the bloodstream. This level becomes very high soon after initial infection, then drops until it returns with the onset of AIDS. Drug therapy can keep viral load low or undetectable, but the client can still infect others since the virus still exists--it is simply not visible. Even when testing reveals a low viral load, HIV continues to live inside certain cells in the body and can begin reproducing at any time if the infected person is not on effective treatment. If a person is not in treatment, HIV produces billions of new virions (viral particles) every day.

Appendix C -- 1993 Revised Classification System For HIV Infection and Expanded AIDS Surveillance Case Definition For Adolescents and Adults

1993 Revised Classification System for HIV Infection and Expanded AIDS Surveillance Case Definition for Adolescents and Adults

CD4+ T cells

Clinical Categories

(A) Symptomatic, Acute (Primary) HIV or PGL*

(B) CD4+ T cells Symptomatic, Not (A) or (C) Conditions

(C) AIDS-Indicator Conditions

(1) >500/mL

A1

B1

C1

(2) 200-499/mL

A2

B2

C2

(3) <200/mL
AIDS-Indicator T-cell count

>A3

B3

C3

(Shaded area indicates that the individual has AIDS.)

PGL-persistent generalized lymphadenopathy. Clinical Category A includes acute (primary) HIV infection.

CD4+ T-Lymphocyte Categories

The three CD4+ T-lymphocyte categories are defined as follows:

These categories correspond to CD4+ T-lymphocyte counts per mL of blood and guide clinical and therapeutic actions in the management of HIV-infected adolescents and adults. The revised HIV classification system also allows for the use of the percentage of CD4+ T cells.

HIV-infected persons should be classified based on existing guidelines for the medical management of HIV-infected persons. Thus, the lowest accurate, but not necessarily the most recent, CD4+ T lymphocyte count should be used for classification purposes.

Clinical Categories

The clinical categories of HIV infection are defined as follows:

Category A

Category A consists of one or more of the conditions listed below in an adolescent or adult (> 13 years) with documented HIV infection. Conditions listed in Categories B and C must not have occurred.

Category B

Category B consists of symptomatic conditions in an HIV-infected adolescent or adult that are not included among conditions listed in clinical Category C and that meet at least one of the following criteria:

For classification purposes, Category B conditions take precedence over those in Category A. For example, someone previously treated for oral or persistent vaginal candidiasis (and who has not developed a Category C disease) but who is now asymptomatic should be classified in clinical Category B.

Category C

Category C includes the clinical conditions listed in the AIDS surveillance case definition (below). For classification purposes, once a Category C condition occurs, the person will remain in Category C.

*This expanded definition requires laboratory confirmation of HIV infection in persons with a CD4+T lymphocyte count of fewer than 200 cells/mL or with an added clinical condition.

**Added as AIDS-defining illness in the 1993 expansion of the AIDS surveillance case definition, when occurring in persons with HIV infection.

Source: Castro et al., 1992.

Appendix D --Screening Instruments

Symptoms Checklist

Symptoms Checklist

Symptom

Question/Action

  • Fever
  • Loss of appetite
  • Weight loss
  • Night sweats
  • Nausea
  • Diarrhea
  • Lymph node swelling
  • HIV positive? Ask about the possibility of HIV. Get an HIV test.
  • Ask about change in diet.
  • Active drug use? Injection-related bacterial infections, cocaine use, and heroin withdrawal are possible causes.
  • Ask about tuberculosis (suggest the Mantoux Purified Protein Derivative [PPD] test).
  • Ask if the client is taking any new illicit drugs or medications; some symptoms may be side effects. See the medical professional before stopping medicines.
  • Is there another infection? See medical professional for diagnosis and treatment, especially if the CD4+ T cell count is low (< 200).
  • Cough
  • Chest pain
  • Shortness of breath
  • HIV positive? Ask about the possibility of HIV. Get an HIV test.
  • Smoking of tobacco or drugs?
  • Exposure to TB? Cough lasting more than 3 weeks should be checked.
  • Fever and night sweats? Pneumonia usually causes these symptoms along with a fever, with or without chills and night sweats.
  • Forgetfulness
  • Psychosis
  • Seizures
  • HIV positive? Ask about the possibility of HIV. Get an HIV test.
  • Intoxication with drugs or alcohol? Withdrawal?
  • Head injury? Immediate medical attention may be needed. HIV-related infection or cancer in the brain may occur, especially if the CD4+ T cell count is low (< 200).
  • Ask about a history of depressive or dissociative symptoms.
  • Ask about a history of psychotic symptoms.
  • Numbness or tingling in the limbs
  • HIV positive? Ask about the possibility of HIV. Get an HIV test.
  • Is didanosine (Videx), zalcitabine (Hivid), or stavudine (D4T) being taken? Contact medical professional immediately.
  • Is there long-term alcohol use or diabetes? See a medical professional.
  • If HIV positive, are antiretroviral medicines working well, are they being taken correctly? Medication resistance or failure to take medicines can make HIV symptoms worse.
  • If there is any numbness or tingling in the limbs, the client should see a medical professional.
  • Rash
  • Itching
  • HIV positive? Ask about the possibility of HIV. Get an HIV test.
  • Hepatitis from drug or alcohol use? See a medical professional.
  • Injection site cellulitis? See a medical professional.
  • Ask if the client is taking any new medications; some symptoms may be side effects. See the medical professional before stopping medicines.

Amsler Grid Test

This instrument is an effective screening tool for early detection of cytomegalovirus. An Amsler grid can help you monitor your central visual field. It can detect early and subtle visual changes resulting from several macular diseases such as age-related macular degeneration and diabetic macular edema. It is also helpful in tracking changes in vision once they have been discovered. The Amsler grid tests each eye separately. This helps you to recognize visual symptoms that are only in one eye.

The above are examples of two different Amsler grids. Both are useful for monitoring central vision. The grid on the right is a modified Amsler grid (Yannuzzi card) intended to be carried in the wallet or purse for daily self-assessment.

Instructions

Ask yourself the following questions as you check each eye separately:

Note: If using a rectangular card like the one on the right above (Yannuzzi card), you should check each eye with the card held both vertically and horizontally.

If the answer to any of these questions is "yes" (and this is a new finding for you), you should contact your doctor immediately for an examination. Sometimes these changes may mean that there is leakage in the back of the eye causing swelling of the retina.

Examples of Abnormal Amsler Grids

Appendix E -- Sample Codes of Ethics

Code of Ethics for Programs Treating Persons With HIV/AIDS And Substance Abuse Disorders

Nondiscrimination

Respect for Client Autonomy

Confidentiality and Accuracy Of Records

Competent and Humane Treatment

Client Orientation

Grievance Procedures

Discharge Policy

Code of Ethics for Therapists and Counselors Who Treat Persons With HIV/AIDS And Substance Abuse Disorders

Nondiscrimination

Respect for Client Autonomy

Confidentiality and Accuracy Of Records

Competent and Humane Treatment

Appendix F -- AIDS-Related Web Sites

INFORMATION SOURCES

The National AIDS Treatment Information Project

http://www.natip.org/index.html

The Measurement Group

www.themeasurementgroup.com

JAMA HIV-AIDS information center

http://www.ama-assn.org/special/ hiv/hivhome.htm

Critical Path AIDS Project

http://www.critpath.org/critpath.htm

HIV/AIDS Treatment Information Service (ATIS)

http://www.hivatis.org

AIDS Clinical Trial Information Service (ATCTIS)

http://www.actis.org

Centers for Disease Control and Prevention (CDC)

http://www.cdc.gov

SFAF/BETA

San Francisco AIDS Foundation home page

http://www.sfaf.org

Bulletin of Experimental Treatments for AIDS

http://www.sfaf.org/beta

Spanish BETA

http://www.sfaf.org/betaespanol/

Positive News/Noticias Positivas

http://www.sfaf.org/treatment/positivenews/

Other online sources of BETA:

http://www.critpath.org/newsletters/beta

http://www.aegis.com/search/

LIBRARIES

National Library of Medicine/MEDLINE

http://www.nlm.nih.gov

Internet Grateful Med

http://access.nlm.nih.gov -or- http://igm.nlm.nih.gov

JAMA AIDSLINE search

http://www.healthgate.com/choice/AMA/search.html

Medscape HIV/AIDS

http://HIV.medscape.com/Home/Topics/AIDS/AIDS.html

Medscape MEDLINE search

http://www.medscape.com/Clinical/Misc/ FormMedlineInfLive.mhtml

HealthGate MEDLINE search

http://www.healthgate.com/HealthGate/MEDLINE/search.shtml

San Francisco Public Library

http://sfpl.lib.ca.us

UCSF Library (Galen)

http://www.library.ucsf.edu

University of San Francisco Library

http://hivinsite.ucsf.edu/

New York Online Access to Health (NOAH)

http://www.noah.cuny.edu/

AIDS-SPECIFIC SITES

AEGIS: AIDS Education Global Information System

http://www.aegis.com/

AIDS Action Committee's subject bibliography to HIV literature

http:www.aac.org/hivtreat/index/subj.html

AIDS NYC

http://www.aidsnyc.org

Asian and Pacific Island Coalition on HIV/AIDS

http://www.aidsinfonyc.org/apicha/home.html

The Body HIV/AIDS site

http://www.thebody.com

Center for AIDS Prevention Studies (UCSF) CAPSweb

http://www.epibiostat.ucsf.edu/capsweb

HIV/AIDS Outreach Project (Vanderbilt)

http://www.mc.vanderbilt.edu/adl/aidsproject

HIVInsite (UCSF)

http://hivinsite.ucsf.edu

HIVnet, Amsterdam

http://www.hivnet.org

HIVpositive - comprehensive resource for PWA

http://www.HIVpositive.com

Immunet, HIV/AIDS information resources for providers

http://www.immunet.org

JAMA's HIV/AIDS information center

http://www.ama-assn.org/special/hiv/ hivhome.htm

News briefings and current articles

http://www.ama-assn.org/special/hiv/newsline

Johns Hopkins AIDS Service

http://www.hopkins-aids.edu

http://www.infoweb.org

JRI Health's InfoWeb (Boston)

http://www.infoweb.org

Marty Howard's AIDS resource page

http://www.smartlink.net/~martinjh/

Edward King's AIDS pages

http://www.eking.dircon.co.uk

Queer Resources Directory AIDS links

http://abacus.oxy.edu/qrd/health/aids

Project Reggie, San Francisco HIV services

http://www.reggie.org

Search for a Cure

http:www.searchforacure.org

San Francisco General Hospital AIDS Program

http://sfghaids.ucsf.edu

AIDS ORGANIZATIONS

ACT UP/Golden Gate

http://www.actupgg.org

ACT UP/New York

http://www.actupny.org

AIDS Action Committee, Boston

http://www.aac.org

AIDS Project Los Angeles

http://www.apla.org

East Harlem HIV Care Network

http://www.aidsnyc.org/network

AIDS Research Information Center

http://www.critpath.org/aric

Critical Path Project, Philadelphia

http://www.critpath.org

Gay Men's Health Crisis

http://www.gmhc.org

Harvard AIDS Institute

http://www.hsph.harvard.edu/Organizations/hai

The Lambda Center

http://www.lambdacenter.com/index.htm

National AIDS Treatment Advocacy Project (Jules Levin)

http://www.natap.org

Project Inform

http://www.projinf.org

Stop AIDS Project

http://www.stopaids.org

Treatment Action Group

http://www.thebody.com/tag/tagpage.html

UCSF AIDS Health Project

http://www.ucsf-ahp.org/

AIDS/MEDICAL PUBLICATIONS

AIDS Journal

http://www.aidsonline.com

AIDS Treatment News

http://www.aidsnews.org/aidsnews/index.html

AIDS Weekly Plus (CW Henderson) (table of contents and abstracts)

http://www.NewsRx.com

British Medical Journal (full text articles)

http://www.bmj.com/bmj

Clinical Care Options for HIV

http://www.usc.edu/hsc/nml/e-resources/info/ClinCarehiv.html

Doctor's Guide to AIDS Information and resources

http://www.pslgroup.com/AIDS.htm

International Association of Physicians in AIDS Care Web site

http://www.iapac.org

Library of the National Medical Society

http://www.medical-library.org/

Journal of the American Medical Association (JAMA) (full text articles available to registrants)

http://www.ama-assn.org/public/journals/ jama/jamahome.htm

The Lancet (full text articles available to registrants)

http://www.thelancet.com

The Merck Manual online

http://www.merck.com/pubs/

AIDS Knowledge Base

http://hivinsite.ucsf.edu/

Morbidity & Mortality Weekly Report (full text, requires PDF viewer)

http://www.cdc.gov/mmwr/

Nature Magazine (summaries and News and Views available)

http://www.nature.com

Nature Medicine (contents and abstracts available)

http://medicine.nature.com

New England Journal of Medicine (contents and abstracts available)

http://www.nejm.org

Science Magazine (contents, abstracts and full text articles available)

http://sciencemag.org/

Scientific American

http://www.sciam.com

Treatment Issues (GMHC)

http://www.gmhc.org/living/treatmnt.html

NEWSPAPERS, MAGAZINES

Multiple newspaper/news service headlines from Aegis

http://www.aegis.com/newslines.html

CNN Interactive

http://www.cnn.com

The Gate: San Francisco Chronicle and Examiner

http://www.sfgate.com

Registration: lizbr/ysw2x

Mercury Center (San Jose Mercury News)

http://www.sjmercury.com

New York Times On the Web

http://www.nytimes.com

GOVERNMENT AND NONGOVERNMENT INFO SITES

Centers for Disease Control and Prevention (CDC)

http://www.cdc.gov

CDC National AIDS Clearinghouse

http://www.cdcnpin.org/

Wonder, database of CDC reports

http://wonder.cdc.gov

AIDS Clinical Trials Information Service

http://www.actis.org or

http://www.hivactis.org

HIV AIDS Treatment Information Service

http://www.hivatis.org

U.S. Department of Health and Human Services comprehensive health information

http://www.healthfinder.gov

National Institutes of Health

http://www.nih.gov

National Institute of Allergies and Infectious Diseases (includes latest news, news archive)

http://www.niaid.nih.gov

Office of the Federal Register

http://www.nara.gov/fedreg/

World Health Organization

http://www.who.org

Joint United Nations Programme on HIV/AIDS

http://www.unaids.org

HIV/AIDS GLOSSARIES

ATIS Glossary (plain text)

http://www.cdcnpin.org/

JAMA HIV/AIDS Information Center

http://www.ama-assn.org/special/hiv

POLICY/ADVOCACY

AIDS Action Council

http://www.thebody.com/aac/aacpage.html

National Association of People with AIDS (NAPWA)

http://www.napwa.org/

TREATMENT ACCESS/ADAP

East Harlem HIV Care Network

http://www.aidsnyc.org/network/

California ADAP

http://sfghaids.ucsf.edu/research.html

Patient Assistance Programs

http://sfghaids.ucsf.edu/people.html

Compassionate use, expanded access, and TIND

http://sfghaids.ucsf.edu/resources.html

CLINICAL TRIALS LISTINGS

AIDS Clinical Trials Information Service

http://www.actis.org

Centerwatch, international trails listing, information on newly approved drugs

http://www.centerwatch.com/main.htm

HIV/AIDS trials listing

http://www.centerwatch.com/CAT2.HTM

Community Programs for Clinical Research on AIDS (CRCRA) home page

http://www.cpcra.org

Trials Search, California clinical trials

http://sfghaids.ucsf.edu/research.html

U.S. clinical trials (compiled by Community Consortium)

http://hivinsite.ucsf.edu/

DRUG/PHARMACEUTICAL SITES

Anti-HIV drug database (HIV Insite)

http://arvdb.ucsf.edu/

Pharmaceutical Information Network

http://pharminfo.com/drugdb/db_mnu.html

Drug interactions

http://www.hivatis.org/fdachart.html

Community Prescription Service

http://www.prescript.com/

FDA drug information

http://www.fda.gov/cder/drug/default.htm

Pharminfo (includes drug database)

http://www.pharminfo.com

http://www.abbott.com

http://www.agouron.com

http://www.fightinfection.com/bms/hiv.htm

http://www.chiron.com

http://www.glaxowellcome.co.uk

http://www.merck.com

http://www.pharmacia.se

http://www.roche.com

http://www.roxane.com/ (Roxane Pain Institute)

GENERAL MEDICAL SITES

Medscape

http://www.medscape.com

MEDICAL SPECIALTIES

Alternative therapy sites:

http://www.teleport.com/~amrta (AMRTA)

http://www.bastyr.edu/research/buarc/ (Bastyr University)

Cancer information

http://oncolink.upenn.edu/cancernet

Oncolink

http://www.nci.nih.gov/

NCI's Cancernet

http://www.graylab.ac.uk/cancernet.html

Hepatitis information site

http://www.hepnet.com

Pain Management

http://www.roxane.com

Tuberculosis resources

http://www.cpmc.columbia.edu/resources/tbcpp/

Virology information

http://www.tulane.edu/~dmsander/garryfavwebindex.html

New York Times women's health

http://www.nytimes.com/women

CONFERENCES

Conference on Retroviruses and OI

http://www.idsociety.org

Conference listings

http://www.immunet.org/confcalendar

FUNDING

Substance Abuse Prevention and Treatment Block Grant text (CDC grants and cooperative agreements on a variety of topics, including HIV/AIDS)

www.cdc.gov/funding.htm

National Institutes of Health Funding Opportunities

http://grants.nih.gov/grants/

Foundation Center

www.fdncenter.org

Local/State Funding Report

www.grantsandfunding.com

HRSA

www.hrsa.dhhs.gov

HUD

www.hud.gov

Join Together

www.jointogether.org

CMHS

www.samhsa.gov/cmhs

CSAT

www.samhsa.gov/csat

Substance Abuse Treatment Improvement Exchange -- includes a listing of the current SSA Directors

www.treatment.org

MISCELLANEOUS

AIDS Patent Library

http://patents.cnidr.org/

The Center Gender Identity Project

http://www.gaycenter.org/programs/mhss/gip.html

HPP/Prevention Point Needle Exchange

http://www.sfaf.org/prevention/

Drug Reform Coalition's needle exchange site

http://www.drcnet.org/gateway/nep.html

North American Syringe Exchange Network

http://www.nasen.org/NASEN_II/index.html

Safe Works Needle Exchange page

http://www.safeworks.org

Queer Resources Directory

http://www.qrd.org/

The Safer Sex Pages

http://www.safersex.org

Service guide for San Francisco (health clinics, shelters, etc)

http://thecity.sfsu.edu/~coleman/pguide.html

Appendix G -- State and Territorial Health Agencies/Offices of AIDS

Listed immediately following each State's name is the State's HIV/AIDS Hotline telephone number, which provides free and anonymous information and referral to services.

ALABAMA

Hotline: (800) 228-0469

Alabama Department of Public Health

Division of HIV/AIDS Prevention and Control

RSA Tower

201 Monroe Street

Suite 1400

Montgomery, AL 36104

Phone: (334) 206-5364; Fax: (334) 206-2092

Web site: http://www.alapubhealth.org/ inform/hiv/frames7.htm

ALASKA

Hotline: (800) 478-2437

Alaska Department of Health and Social Services

Division of Public Health

350 Main Street, Room 503

Juneau, AK 99801

Phone: (907) 465-3090; Fax: (907) 586-1877

Web site: http://epi.hss.state.ak.us/ (See "Section on Epidemiology" for HIV/AIDS information.)

ARIZONA

Hotline: (800) 352-3792

Arizona Department of Health Services

Bureau of Epidemiology & Disease Control Services

3815 North Black Canyon

Phoenix, AZ 85015

Phone: (602) 230-5808; Fax: (602) 230-5959

Arizona Office of HIV/STD Services

Phone: (602) 230-5819

Web site: http://www.hs.state.az.us/edc/ hivpage.html#help

ARKANSAS

Hotline: (800) 482-5400

Arkansas Department of Health

AIDS/STD Section

Arkansas Department of Health

4815 West Markham Street, Mailstop 33

Little Rock, AR 72205-3867

Phone: (501) 661-2111; Fax: (501) 671-1450

Web site: http://health.state.ar.us

CALIFORNIA

Hotline: (800) 367-AIDSTDD: (888) 225-AIDS

California Department of Health Services

Office of AIDS

611 North 7th Street